CNTF, His

Alternative Names: Ciliary Neurotrophic Factor, CNTF, HCNTF

CNTF is a neurotrophic factor that primarily acts on the nervous system by promoting neurotransmitter synthesis and neurite outgrowth in specific neuronal populations. It is crucial for the survival of neurons and oligodendrocytes, potentially reducing tissue damage during inflammatory responses. Mutations in the CNTF gene, specifically those affecting splicing, can result in ciliary neurotrophic factor deficiency. This deficiency, however, is not directly linked to neurologic diseases. The gene is transcribed alone as well as in conjunction with the ZFP91 gene, resulting in a transcript containing the complete coding region for the zinc finger protein but lacking the full coding region for CNTF.

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  • Sku: PSB-cyt-573-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Ciliary Neurotrophic Factor, His Tag is a protein belonging to the ciliary neurotrophic factor family. This protein plays a role in the survival and differentiation of various neuronal cell types. With a molecular weight of approximately 22 kDa, Recombinant Human Ciliary Neurotrophic Factor, His Tag is commonly used in research settings to study the effects of neurotrophic factors on neuronal development and function.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CNTF protein solution (1mg/ml) contains 20mM Tris-HCl buffer pH-8 and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAFTEHSPLT PHRRDLCSRS IWLARKIRSDLTALTESYVK HQGLNKNINL DSADGMPVAS TDQWSELTEA ERLQENLQAY RTFHVLLARL LEDQQVHFTP TEGDFHQAIH TLLLQVAAFA YQIEELMILL EYKIPRNEAD GMPINVGDGG LFEKKLWGLK VLQELSQWTV RSIHDLRFIS SHQTGIPARG SHYIANNKKM.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CNTF, His

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