CNTF

Alternative Names: Ciliary Neurotrophic Factor, CNTF, HCNTF

CNTF is a polypeptide hormone with specific actions in the nervous system, promoting neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. It acts as a survival factor for neurons and oligodendrocytes, potentially reducing tissue damage during inflammation. A mutation in the gene can cause ciliary neurotrophic factor deficiency, but this is not directly linked to neurological diseases. The gene is co-transcribed with the upstream ZFP91 gene, resulting in a transcript that lacks the full coding region for CNTF but contains the coding region for the zinc finger protein.

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  • Sku: PSB-cyt-272-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Ciliary Neurotrophic Factor (rhCNTF) is a protein belonging to the neurotrophin family, known for its role in promoting the survival and differentiation of various neuronal cell types. With a molecular weight of approximately 22 kDa, rhCNTF has shown potential therapeutic applications in the treatment of neurodegenerative diseases and nerve injuries. This recombinant protein is produced through genetic engineering techniques, offering a promising avenue for further research and development in the field of neurobiology.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 The ED50 as determined by the dose-dependant stimulation of TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 500,000IU/mg. The ED50 as determined by the dose-dependant stimulation of TF-1 cells is < 2 ng/ml, corresponding to a Specific Activity of 500,000IU/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Lyophilized from a concentrated (1mg/ml) solution in water containing 5mM sodium Phosphate buffer pH=7.5 and 5mM sodium chloride.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Phe-Thr-Glu.

Storage Instruction

Lyophilized Ciliary Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CNTF should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized HCNTF in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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CNTF
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