CMPK1

Alternative Names: UMP/CMP kinase, UMP/CMPK, CMPK1, CMK, CMPK, UCK, UMK, UMPK, UMP-CMPK, Uridine monophosphate kinase, Uridine monophosphate/cytidine monophosphate kinase, Cytidine monophosphate kinase, Cytidylate kinase, Deoxycytidylate kinase, RP11-511I2.1.

UMP-CMP kinase, also known as CMPK1, is an enzyme that facilitates the transfer of a phosphate group from ATP to UMP, CMP, and dCMP. This reaction produces ADP and the corresponding nucleoside diphosphate, which are vital for the synthesis of cellular nucleic acids. Additionally, CMPK1 plays a crucial role in activating pyrimidine analogs, which are valuable in treating cancer and viral infections.

  •
  • Sku: PSB-pka-002-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Cytidine Monophosphate Kinase 1 (CMPK1) is an enzyme that plays a vital role in the biosynthesis of nucleotides, specifically cytidine triphosphate (CTP), which is essential for DNA and RNA synthesis. Belonging to the kinase family, CMPK1 catalyzes the phosphorylation of cytidine monophosphate (CMP) to generate CTP, utilizing ATP as a phosphate donor. With a molecular weight of approximately 34 kilodaltons, CMPK1 is involved in maintaining cellular nucleotide pools and is crucial for proper cellular function.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CMPK1 solution (1mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol, 1mM DTT and 100mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MLSRCRSGLL HVLGLSFLLQ TRRPILLCSP RLMKPLVVFV LGGPGAGKGT QCARIVEKYG YTHLSAGELL RDERKNPDSQ YGELIEKYIK EGKIVPVEIT ISLLKREMDQ TMAANAQKNK FLIDGFPRNQ DNLQGWNKTM DGKADVSFVL FFDCNNEICI ERCLERGKSS GRSDDNRESL EKRIQTYLQS TKPIIDLYEE MGKVKKIDAS KSVDEVFDEV VQIFDKEG.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CMPK1
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