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Clusterin, His

Alternative Names: CLI, AAG4, APOJ, Clusterin, ging-associated gene 4 protein, Apolipoprotein J, Complement cytolysis inhibitor, Complement-associated protein SP-40,40, Ku70-binding protein 1, SGP2, SGP-2, SP-40, TRPM2, TRPM-2, MGC24903, NA1/NA2, Testosterone-repressed prostate message 2, CLU.

Clusterin, also known as Apolipoprotein J (APO-J), is a 75-80 kD disulfide-linked heterodimeric protein enriched with sialic acid. Truncated forms that target the nucleus have been identified. The precursor polypeptide chain is cleaved proteolytically to remove the secretory signal peptide and generate two chains, a and b. These chains are assembled in an anti-parallel manner, forming a heterodimeric molecule. Clusterin shows a high degree of sequence homology across various species, ranging from 70% to 80%. It is expressed in most mammalian tissues and can be found in bodily fluids such as plasma, milk, urine, cerebrospinal fluid, and semen. Clusterin has the ability to bind and form complexes with numerous partners, including immunoglobulins, lipids, and bacteria. It has been associated with functions such as phagocyte recruitment, apoptosis inhibition, and lipid transport. The exact function of clusterin remains unclear, but one hypothesis suggests that it acts as an extracellular chaperone protecting cells from stress-induced insult caused by degraded proteins. Clusterin is known to be up- or down-regulated in various pathological conditions, including cancer, Alzheimer's disease, and autoimmunity.

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  • Sku: PSB-cyt-814-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Apolipoprotein-J, His Tag is a protein belonging to the apolipoprotein family, which plays a crucial role in lipid metabolism and transport. With a molecular weight of approximately 40 kDa, this protein is commonly used in research and biotechnological applications due to its ability to bind to lipids and regulate cholesterol levels. The His Tag attached to the protein allows for easy purification and detection in experimental settings.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 54.1 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Clusterin protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSDQTV SDNELQEMSN QGSKYVNKEI QNAVNGVKQI KTLIEKTNEE RKTLLSNLEE AKKKKEDALN ETRESETKLK ELPGVCNETM MALWEECKPC LKQTCMKFYA RVCRSGSGLV GRQLEEFLNQ SSPFYFWMNG DRIDSLLEND RQQTHMLDVM QDHFSRASSI IDELFQDRFF TREPQDTYHY LPFSLPHRRP HFFFPKSRIV RSLMPFSPYE PLNFHAMFQP FLEMIHEAQQ AMDIHFHSPA FQHPPTEFIR EGDDDRTVCR EIRHNSTGCL RMKDQCDKCR EILSVDCSTN NPSQAKLRRE LDESLQVAER LTRKYNELLK SYQWKMLNTS SLLEQLNEQF NWVSRLANLT QGEDQYYLRV TTVASHTSDS DVPSGVTEVV VKLFDSDPIT VTVPVEVSRK NPKFMETVAE KALQEYRKKH REE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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Clusterin, His
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