CLTB

Alternative Names: CLTB, Clathrin light chain B, Lcb

Clathrin light chain B (CLTB) is a member of the clathrin light chain family and plays a crucial role in the formation of coated vesicles. It acts as the main component of the lattice-type cytoplasmic face of coated pits and vesicles, which capture certain macromolecules during receptor-mediated endocytosis. CLTB combines with clathrin heavy chains to form a triskelion structure, consisting of three clathrin heavy chains and three light chains. These triskelia interact to create a polyhedral pattern that surrounds the vesicle. Clathrin-mediated endocytosis (CME) is a vital process that controls various cellular functions, including the internalization of growth factors and receptors, the entry of pathogens, and synaptic transmission.

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  • Sku: PSB-pro-1172-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Clathrin, Light Chain B is a protein that plays a vital role in intracellular vesicle trafficking. Belonging to the clathrin protein family, it is responsible for the formation of clathrin-coated vesicles, which are involved in the transport of various molecules within cells. With a weight of approximately X kDa, this protein is crucial for maintaining cellular homeostasis and regulating cellular processes. Its significance lies in its ability to facilitate the selective transport of cargo molecules, ensuring proper cellular function.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 25.6 kDa
Structure Triskelion
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CLTB protein solution (1mg/ml) containing 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 0.2mM PMSF and 100mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMADDFGF FSSSESGAPE AAEEDPAAAF LAQQESEIAG IENDEGFGAP AGSHAAPAQP GPTSGAGSED MGTTVNGDVF QEANGPADGY AAIAQADRLT QEPESIRKWR EEQRKRLQEL DAASKVTEQE WREKAKKDLE EWNQRQSEQV EKNKINNRAS EEAFVKESKE ETPGTEWEKV AQLCDFNPKS SKQCKDVSRL RSVLMSLKQT PLSR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CLTB
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