CLIC2

Alternative Names: APG3, APG3-LIKE, APG3L, Ubiquitin-like-conjugating enzyme ATG3, Autophagy-related protein 3, hApg3, PC3-96, PC3-96, ATG3.

ATG3 is a key enzyme involved in Cvt, autophagy, and maintaining mitochondrial homeostasis. It is primarily found in the cytoplasm, with high expression in the kidney, placenta, liver, heart, and skeletal muscle. Its main function is catalyzing the formation of the ATG-PE conjugate, which is critical for autophagy.

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  • Sku: PSB-pro-198-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Chloride Intracellular Channel 2 (CLIC2) is a protein that belongs to the chloride intracellular channel (CLIC) family. With a molecular weight of approximately 27 kDa, CLIC2 plays a significant role in various cellular processes. It functions as an ion channel, facilitating the movement of chloride ions across cell membranes, thereby regulating cellular homeostasis. CLIC2 has been implicated in diverse physiological and pathological conditions, including cell proliferation, apoptosis, and cancer progression. Understanding the intricate mechanisms underlying CLIC2's involvement in these processes is crucial for unraveling its potential therapeutic implications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
38.3 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation ATG3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMQNVINT VKGKALEVAE YLTPVLKESK FKETGVITPE EFVAAGDHLV HHCPTWQWAT GEELKVKAYL PTGKQFLVTK NVPCYKRCKQ MEYSDELEAI IEEDDGDGGW VDTYHNTGIT GITEAVKEIT LENKDNIRLQ DCSALCEEEE DEDEGEAADM EEYEESGLLE TDEATLDTRK IVEACKAKTD AGGEDAILQT RTYDLYITYD KYYQTPRLWL FGYDEQRQPL TVEHMYEDIS QDHVKKTVTI ENHPHLPPPP MCSVHPCRHA EVMKKIIETV AEGGGELGVH MYLLIFLKFV QAVIPTIEYD YTRHFTM.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CLIC2

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