CLCF1

Alternative Names: Cardiotrophin-like cytokine factor 1, CLCF1, B-cell-stimulating factor 3, BSF-3, Novel neurotrophin-1, NNT-1, BSF3, CLC, NNT1, NR6, CISS2.

CLCF1 is a cytokine belonging to the IL-6 family, involved in cell signaling through gp130 phosphorylation. It consists of 225 amino acids, including a 27 aa signal peptide, with a mature form weighing 22kDa. CLCF1 closely resembles cardiotrophin-1 and ciliary neurotrophic factor. The cytokine is secreted by cells in association with soluble type I CRLF1 or soluble CNTFR. Mutations in the CLCF1 gene lead to cold-induced sweating syndrome 2 (CISS2), characterized by excessive sweating and developmental abnormalities of the head and spine.

Skip to product information
  • Sku: PSB-cyt-071-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
 per 
Shipping calculated at checkout.

Contact us directly for international purchases.

Title

Product Details

Product Description

Recombinant Human Cardiotrophin-Like Cytokine Factor 1 (CLCF1) is a member of the interleukin-6 (IL-6) cytokine family, known for its involvement in various biological processes including cell growth and differentiation. CLCF1 is a glycoprotein with a molecular weight of approximately 30 kDa. This cytokine plays a role in inflammation, immune response, and hematopoiesis, making it a valuable target for research and therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
24.6 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CLCF1 protein solution (1mg/ml) containing 20mM sodium citrate (pH 3.5), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MLNRTGDPGP GPSIQKTYDL TRYLEHQLRS LAGTYLNYLG PPFNEPDFNP PRLGAETLPR ATVDLEVWRS LNDKLRLTQN YEAYSHLLCY LRGLNRQAAT AELRRSLAHF CTSLQGLLGS IAGVMAALGY PLPQPLPGTE PTWTPGPAHS DFLQKMDDFW LLKELQTWLW RSAKDFNRLK KKMQPPAAAV TLHLGAHGF.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

View full details

CLCF1

SUBHEADING

Recently viewed products