CKMT2

Alternative Names: Creatine kinase mitochondrial 2 (sarcomeric), Sarcomeric mitochondrial creatine kinase, Basic-type mitochondrial creatine kinase, creatine kinase S-type, mitochondrial, Mib-CK, SMTCK, EC 2.7.3.2.

Creatine Kinase, Mitochondrial 2 (CKMT2) belongs to the ATP:guanido phosphotransferase family. It facilitates the transfer of high energy phosphate from mitochondria to the creatine carrier in the cytosol. This enzyme plays a reversible role in the transfer of phosphate between ATP and various phosphogens, such as creatine phosphate. Creatine kinase isoenzymes are essential for energy transduction in tissues with fluctuating energy demands, including skeletal muscle, heart, brain, and spermatozoa. Unlike cytosolic creatine kinase isoenzymes, mitochondrial creatine kinase exists in two forms: dimers and octamers. The CKMT2 gene contains sequences with similarity to motifs found in nuclear genes that encode mitochondrial proteins. These motifs may be important for the coordinated activation of genes involved in mitochondrial biogenesis.

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  • Sku: PSB-cki-276-5µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Human Creatine Kinase, Mitochondrial 2 is an enzyme that plays a significant role in cellular energy metabolism. Belonging to the creatine kinase family, it is primarily found in the mitochondria, the powerhouse of cells. With a molecular weight of approximately [insert weight], this enzyme catalyzes the reversible transfer of a phosphate group from phosphocreatine to ADP, generating ATP, the main energy currency of the cell. Its precise function and regulation make it a subject of interest in various scientific studies and research endeavors.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CKMT2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.1M NaCl, 1mM DTT and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMEVREQ PRLFPPSADY PDLRKHNNCM AECLTPAIYA KLRNKVTPNG YTLDQCIQTG VDNPGHPFIK TVGMVAGDEE SYEVFADLFD PVIKLRHNGY DPRVMKHTTD LDASKITQGQ FDEHYVLSSR VRTGRSIRGL SLPPACTRAE RREVENVAIT ALEGLKGDLA GRYYKLSEMT EQDQQRLIDD HFLFDKPVSP LLTCAGMARD WPDARGIWHN YDKTFLIWIN EEDHTRVISM EKGGNMKRVF ERFCRGLKEV ERLIQERGWE FMWNERLGYI LTCPSNLGTG LRAGVHVRIP KLSKDPRFSK ILENLRLQKR GTGGVDTAAV ADVYDISNID RIGRSEVELV QIVIDGVNYL VDCEKKLERG QDIKVPPPLP QFGKK

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CKMT2
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