CKB His

Alternative Names: EC 2.7.3.2, CKB, CKBBB, B-CK, Creatine kinase B chain, Creatine kinase B type, Creatine Kinase Brain.

CKB is an intracellular enzyme involved in maintaining energy balance. It facilitates the transfer of phosphate between ATP and other phosphogens, like creatine phosphate. In the brain and various tissues, CKB functions as a homodimer, while in the heart, it forms a heterodimer with a similar muscle isozyme. Creatine kinases provide the necessary phosphate hydrolysis energy for the proper functioning of various cellular systems, including muscle, tumor, and cancer cells.

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  • Sku: PSB-cki-274-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Creatine Kinase Brain, His Tag is a protein that belongs to the family of creatine kinases. With a weight of approximately X kDa, this protein plays a significant role in the energy metabolism of the brain. It catalyzes the reversible transfer of a phosphate group from phosphocreatine to ADP, generating ATP, which is crucial for cellular energy homeostasis. The His tag allows for easy purification and detection of the protein in various experimental settings. This recombinant protein is widely used in scientific research to investigate brain energy metabolism and its dysregulation in various neurological disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CKB Human solution containing 20mM Trsi pH-8, 1mM DTT, & 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MPFSNSHNAL KLRFPAEDEF PDLSAHNNHM AKVLTPELYA ELRAKSTPSG FTLDDVIQTG VDNPGHPYIM TVGCVAGDEE SYEVFKDLFD PIIEDRHGGY KPSDEHKTDL NPDNLQGGDD LDPNYVLSSR VRTGRSIRGF CLPPHCSRGE RRAIEKLAVE ALSSLDGDLA GRYYALKSMT EAEQQQLIDD HFLFDKPVSP LLLASGMARD WPDARGIWHN DNKTFLVWVN EEDHLRVISM QKGGNMKEVF TRFCTGLTQI ETLFKSKDYE FMWNPHLGYI LTCPSNLGTG LRAGVHIKLP NLGKHEKFSE VLKRLRLQKR GTGGVDTAAV GGVFDVSNAD RLGFSEVELV QMVVDGVKLL IEMEQRLEQG QAIDDLMPAQ K.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CKB His

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