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chGH Antagonist

Alternative Names: Pituitary growth hormone, Growth hormone 1, Somatotropin, GH1, GH, GHN, GH-N, hGH-N

GH is a hormone that belongs to the somatotropin/prolactin family and is involved in growth control. It is located on chromosome 17 along with four other related genes, and they are arranged in the same orientation due to gene duplication events. These five genes have very similar sequences. Through alternative splicing, different isoforms of each growth hormone can be generated, increasing diversity and potential specialization. This specific hormone is expressed in the pituitary gland but not in placental tissue, unlike the other genes in the growth hormone locus. Mutations or deletions of this gene result in growth hormone deficiency and short stature.

  •
  • Sku: PSB-cyt-538-20µg
  • Vendor: ProSpec-Tany
$130.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

The Recombinant Chicken Growth Hormone Antagonist is a synthetic protein designed to inhibit the action of chicken growth hormone. Belonging to the peptide hormone family, this antagonist acts as a competitive inhibitor, binding to growth hormone receptors and preventing the activation of downstream signaling pathways. With a molecular weight of approximately X kDa, this recombinant protein offers a targeted approach to modulate growth hormone activity in chickens, potentially influencing growth and development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Chicken
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 Recombinant Chicken Growth Hormone G119R mutant did not bind to ovine GHR-ECD and was devoid of any biological activity in FDC-P1 3B9 cells. However, in binding experiments that were carried out using chicken liver membranes, both ovine GH and chicken GH showed similar IC50 values in competition with 125I-ovine GH, while the IC50 of G119R mutein was 10-fold higher. These results emphasize the importance of species specificity and indicate the possibility of antagonistic activity of chGH G119R in homologous system.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a concentrated (1mg/ml) solution with 0.3% NaHCO3 pH-8.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and was found to be Ala-Thr-Phe-Pro-Ala.

Storage Instruction

Lyophilized Growth-Hormone Chicken antagonist although stable at room temperature for at least two weeks, should be stored desiccated below -18°C. Upon reconstitution and filter sterilization GH can be stored at 4°C, pH 9 for up to 4 weeks. For long term storage and more diluted solutions it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Growth-Hormone Chicken antagonist in 0.4% NaHCO3 or water adjusted to pH 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions, preferably in a presence of a carrier protein such as BSA or similar.

References

Not Available
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chGH Antagonist
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