cGH

Alternative Names: Pituitary growth hormone, Somatotropin, Growth hormone 1, GH, GH1, GH-N, hGH-N

Growth Hormone, a member of the somatotropin/prolactin hormone family, is crucial in controlling growth. It is located on chromosome 17 with four other related genes, arranged in the same transcriptional orientation due to gene duplications. These genes have a high sequence identity and alternative splicing produces different isoforms, allowing for specialization. This particular hormone is expressed in the pituitary but not in placental tissue, unlike the other genes in the locus. Mutations or deletions in the gene can result in growth hormone deficiency and short stature.

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  • Sku: PSB-cyt-297-10µg
  • Vendor: ProSpec-Tany
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Product Details

Product Description

Recombinant Carp Growth Hormone is a synthetic hormone derived from the DNA of carp species. Belonging to the peptide hormone family, it plays a significant role in regulating the growth and development of carp. With a molecular weight of approximately 22 kDa, this hormone is crucial for promoting cell division and protein synthesis in carp, ultimately leading to increased growth rates and improved body size.

Current Lead Time

7-14 Days

Product Specifications

Species
 Carp
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Carp GH is biologically active in rat 3T3 F442A preadipocytes, though its activity is 15-fold lower compared to bovine GH, but it is equally potent in vivo in promoting carp growth (Fine et al.1993). Furthermore, carp GH forms 1:2 complex with the extra cellular domain of ovine growth hormone receptor. Carp GH is biologically active in rat 3T3 F442A preadipocytes, though its activity is 15-fold lower compared to bovine GH, but it is equally potent in vivo in promoting carp growth (Fine et al.1993). Furthermore, carp GH forms 1:2 complex with the extra cellular domain of ovine growth hormone receptor.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The GH Carp was lyophilized from a concentrated (1mg/ml) solution with 0.3% NaHCO3 adjusted to pH 8.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

The sequence of the first five N-terminal amino acids was determined and found to be Ser-Asp-Asn-Gln-Arg.

Storage Instruction

Lyophilized Growth Hormone Carp recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Growth Hormone Carp should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Growth Hormone Carp recombinant in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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cGH
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