CFP

Alternative Names: Properdin, Complement factor P, CFP, PFC, Complement factor properdin, BFD, PFD

Complement Factor Properdin (CFP) is a plasma glycoprotein that plays a key role in regulating the alternative complement pathway of the innate immune system. By binding and stabilizing the C3- and C5-convertase enzyme complexes, CFP initiates a feedback loop that ultimately results in the formation of the membrane attack complex and the lysis of the target cell. Mutations in CFP can cause properdin deficiency, leading to increased vulnerability to meningococcal infections.

  •
  • Sku: PSB-pro-2702-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Complement Factor Properdin, a member of the complement system, is a glycoprotein that plays a vital role in the innate immune response. Belonging to the properdin family, this protein acts as a positive regulator in the alternative pathway of the complement system. With a molecular weight of approximately 53 kilodaltons, Human Complement Factor Properdin stabilizes the C3 convertase enzyme complex, enhancing its enzymatic activity and promoting the opsonization of pathogens. Understanding the functional properties and regulatory mechanisms of this protein is crucial for unraveling the intricate workings of the complement system and its implications in immune-related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 90.0 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 53 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CFP solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CFP
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