CFD

Alternative Names: Complement factor D, CFD, DF, Adipsin, C3 convertase activator, Properdin factor D, PFD.

CFD is a vital part of the alternative pathway of complement activation. It functions by cleaving and activating factor B when it binds C3b or similar proteins like C3 or CVF. CFD is a serine protease that primarily exhibits substrate activation and limited specificity. It performs cleavage of factor B by C3b, resulting in the release of the Ba fragment and leaving Bb fragment attached to C3b. This complex, known as C3 or C5 convertase, converts these proteins into their active forms by removing the small peptides C3a and C5a.

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  • Sku: PSB-pro-2699-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Human Complement Factor D is a serine protease that plays a critical role in the alternative pathway of the complement system. Belonging to the family of trypsin-like serine proteases, this enzyme is responsible for the cleavage of complement factor B, resulting in the generation of the active C3bBb convertase. With a molecular weight of approximately 24 kDa, Human Complement Factor D is involved in the amplification and regulation of the immune response, contributing to the innate immune defense against pathogens.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CFD protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CFD

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