CFB Native

Alternative Names: CFB, C3/C5 convertase, Glycine-rich beta glycoprotein, GBG, PBF2, Properdin factor B, BF, BFD, AHUS4, ARMD14, CFAB, CFBD, FB, FBI12, GBG, H2-Bf

Complement Factor B, or CFB, is a vital component in the alternative pathway of complement activation. This factor exists as a single chain polypeptide in the bloodstream. When the alternative pathway is triggered, complement factor D cleaves Factor B into Ba and Bb. Bb, the active subunit, is a serine protease that binds to C3b to create the alternative pathway C3 convertase. Additionally, Bb plays a role in the growth of preactivated B lymphocytes, while Ba inhibits their proliferation.

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  • Sku: PSB-pro-2698-20µg
  • Vendor: ProSpec-Tany
$220.00 USD
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Title

Product Details

Product Description

Human Complement Factor B is a protein that plays a significant role in the innate immune response. Belonging to the complement system, it is a member of the serine protease family. With a molecular weight of approximately 93 kilodaltons, this protein functions as a crucial component in the alternative pathway of the complement system, aiding in the opsonization and elimination of pathogens. Understanding the properties and functions of Human Complement Factor B contributes to the comprehension of the intricate mechanisms underlying the immune response.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CFB protein solution contains 10mM Sodium phosphate and 145mM NaCl, pH 7.2.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CFB Native

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