CEBP-a

Alternative Names: CEBPA, C/EBP alpha, CCAAT/enhancer-binding protein alpha, CEBP.

CCAAT/enhancer binding protein (C/EBP) is a family of transcription factors that play a crucial role in regulating viral and cellular CCAAT/enhancer element-mediated transcription. These factors, including C/EBP proteins (a, b, g, and d), contain a conserved basic-leucine zipper domain at the C-terminus. This domain is involved in both dimerization and DNA binding. Within the C/EBP family, homodimers and heterodimers can form between different proteins. The bZIP region, found in all C/EBPs, consists of a basic region responsible for DNA binding and a leucine zipper motif essential for dimerization. C/EBPs exhibit diverse physiological functions and control different downstream target genes. For instance, the absence of C/EBPa in mice results in severe hypoglycemia and the inability to store glycogen in the liver, leading to their death shortly after birth. In contrast, the knockout of C/EBPb leads to reproductive defects in female mice.

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  • Sku: PSB-pro-433-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human CCAAT/enhancer binding protein (C/EBP) Alpha is a transcription factor protein that plays a significant role in regulating gene expression and cellular differentiation. Belonging to the C/EBP family, this protein is involved in various physiological processes, including adipogenesis, liver function, and immune response. With a molecular weight of approximately 42 kDa, Recombinant Human C/EBP Alpha is a crucial component in understanding the intricate mechanisms underlying gene regulation and cellular development.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein contains 20mM Tris-HCl pH7.5, 0.1M NaCl and 5mM b-Mercaptoethanol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMGAG KAKKSVDKNS NEYRVRRERN NIAVRKSRDK AKQRNVETQQ KVLELTSDND RLRKRVEQLS RELDTLRGIF RQLPESSLVKAMGNCA.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CEBP-a
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