CDKN3

Alternative Names: Cyclin-dependent kinase inhibitor 3, CDKN3, CDK2-associated dual-specificity phosphatase, Cyclin-dependent kinase interactor 1, CDI1, Cyclin-dependent kinase-interacting protein 2, CIP2, Kinase-associated phosphatase, KAP, KAP1, FLJ25787, MGC70625.

CDKN3, a member of the dual specificity protein phosphatase family, functions as a cyclin-dependent kinase inhibitor by dephosphorylating CDK2 kinase, thus inhibiting its activation. CDKN3 also plays a significant role in cell cycle regulation and has been found to be implicated in various types of cancers through deletion, mutation, or overexpression of the CDKN3 gene.

  •
  • Sku: PSB-pka-336-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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UniProt Listing
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Product Details

Product Description

Recombinant Human Cyclin-Dependent Kinase Inhibitor 3 is a protein inhibitor that belongs to the cyclin-dependent kinase inhibitor family. It is a regulatory protein that plays a role in cell cycle progression by inhibiting the activity of cyclin-dependent kinases. This inhibitor has a molecular weight of approximately 30 kDa and is involved in regulating the cell cycle by controlling the progression of cells through the G1 phase. Its function is to prevent uncontrolled cell division by blocking the activity of cyclin-dependent kinases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 25.9 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CDKN3 solution (0.5 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 40% glycerol and 0.1M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MKPPSSIQTS EFDSSDEEPI EDEQTPIHIS WLSLSRVNCS QFLGLCALPG CKFKDVRRNV QKDTEELKSC GIQDIFVFCT RGELSKYRVP NLLDLYQQCG IITHHHPIAD GGTPDIASCC EIMEELTTCL KNYRKTLIHC YGGLGRSCLV AACLLLYLSD TISPEQAIDS LRDLRGSGAI QTIKQYNYLH EFRDKLAAHL SSRDSQSRSV SR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CDKN3
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