CDKN1B

Alternative Names: Cyclin-dependent kinase inhibitor 1B, CDKN1B, Cyclin-dependent kinase inhibitor p27, p27Kip1, KIP1, CDKN4, MEN1B, MEN4.

CDKN1B, a member of the Cip/Kip family, inhibits cyclin E-CDK2 and cyclin D-CDK4 complexes, controlling G1 cell cycle progression. Known as a cell cycle inhibitor protein, CDKN1B halts or delays cell division. Its degradation, triggered by CDK dependent phosphorylation and ubiquitination by SCF complexes, is necessary for cells to transition to a proliferative state.

  •
  • Sku: PSB-pka-012-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B is a protein that belongs to the cyclin-dependent kinase inhibitor family. It plays a role in regulating the cell cycle by inhibiting the activity of cyclin-dependent kinases. This protein has a molecular weight of approximately 16 kDa. Recombinant Human Cyclin-Dependent Kinase Inhibitor 1B is commonly used in research settings to study cell cycle regulation and potential therapeutic interventions for diseases related to uncontrolled cell growth.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 24.2 kDa
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation CDKN1B protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0) and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MSNVRVSNGS PSLERMDARQ AEHPKPSACR NLFGPVDHEE LTRDLEKHCR DMEEASQRKW NFDFQNHKPL EGKYEWQEVE KGSLPEFYYR PPRPPKGACK VPAQESQDVS GSRPAAPLIG APANSEDTHL VDPKTDPSDS QTGLAEQCAG IRKRPATDDS STQNKRANRT EENVSDGSPN AGSVEQTPKK PGLRRRQT.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CDKN1B
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