CDK2

Alternative Names: Cell division protein kinase 2, Cyclin-dependent kinase 2, CDK2, CDKN2, p33 protein kinase, p33(CDK2)

CDK2 is a Ser/Thr protein kinase that is part of the cyclin-dependent protein kinase complex. It plays a crucial role in the G1-S phase transition of the cell cycle. CDK2 is closely related to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. Its activity is regulated by regulatory subunits such as cyclin A or E, CDK inhibitor p21Cip1, and p27Kip1. Additionally, CDK2 activity is modulated by protein phosphorylation.

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  • Sku: PSB-pka-008-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human cyclin-dependent kinase 2 (CDK2) is a member of the cyclin-dependent kinase family, which plays a critical role in regulating cell cycle progression. With a molecular weight of approximately 34 kDa, CDK2 is involved in the phosphorylation of key proteins that control the transition between different phases of the cell cycle. Its activity is tightly regulated by the binding of specific cyclin proteins, which activate CDK2 and drive cell cycle progression. Recombinant Human CDK2 is commonly used in research settings to study cell cycle regulation and potential therapeutic targets for cancer treatment.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CDK2 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 20% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MENFQKVEKI GEGTYGVVYK ARNKLTGEVV ALKKIRLDTE TEGVPSTAIR EISLLKELNH PNIVKLLDVI HTENKLYLVF EFLHQDLKKF MDASALTGIP LPLIKSYLFQ LLQGLAFCHS HRVLHRDLKP QNLLINTEGA IKLADFGLAR AFGVPVRTYT HEVVTLWYRA PEILLGCKYY STAVDIWSLG CIFAEMVTRR ALFPGDSEID QLFRIFRTLG TPDEVVWPGV TSMPDYKPSF PKWARQDFSK VVPPLDEDGR SLLSQMLHYD PNKRISAKAA LAHPFFQDVT KPVPHLRLLE HHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CDK2

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