CDH1

Alternative Names: CDH1, Cadherin-1, Cadherin-E, CD324, CD324 antigen, CDHE, ECAD, E-cadherin, Epithelial cadherin, Uvomorulin, UVO, LCAM, CAM 120/80, Arc-1

E-cadherin (also known as uvomorulin or cell-CAM120/80) is a cell adhesion molecule that relies on calcium for its function. It is primarily found in epithelial tissues. E-cadherin is crucial for regulating cell growth and development by maintaining tissue integrity and controlling tissue architecture. Research has consistently shown that when the expression of E-cadherin is reduced or lost in carcinomas, it is associated with an increased likelihood of tumor invasion and metastasis.

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  • Sku: PSB-pro-461-2µg
  • Vendor: ProSpec-Tany
$175.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human E-Cadherin is a protein that plays a crucial role in cell adhesion and tissue development. Belonging to the cadherin family, it is primarily involved in calcium-dependent cell-cell adhesion, maintaining the integrity and stability of epithelial tissues. With a molecular weight of approximately 120 kDa, this protein functions as a homophilic cell adhesion molecule, mediating cell-cell interactions and regulating various cellular processes. Recombinant Human E-Cadherin is widely used in research and biotechnological applications for studying cell adhesion mechanisms and tissue engineering.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation Cadherin-E protein (100µg/1ml) in 50mM Tris-HCl, pH7.5 and 10mM L-glutathione (reduced).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

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Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CDH1
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