CD8B, Sf9

Alternative Names: CD8b Molecule, CD8 Antigen, Beta Polypeptide 1 (P37), CD8B1, T Lymphocyte Surface Glycoprotein Beta Chain, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8b Antigen, Leu2, LYT3, P37, LY3, T-cell surface glycoprotein CD8 beta chain

CD8B is responsible for encoding the CD8 beta chain isoforms of the CD8 antigen, a glycoprotein found on most cytotoxic T lymphocytes. This antigen plays a vital role in facilitating cell-cell interactions within the immune system. It serves as a co-receptor alongside the T-cell receptor on T lymphocytes to identify antigens presented by antigen presenting cells. The co-receptor can exist as either a heterodimer or a homodimer, composed of alpha and beta chains or two alpha chains, respectively. It is important to note that both alpha and beta chains have significant homology to immunoglobulin variable light chains.

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  • Sku: PSB-pro-2508-1µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human CD8B, Sf9 is a protein derived from the CD8B gene and expressed in Spodoptera frugiperda (Sf9) insect cells. Belonging to the immunoglobulin superfamily, this protein plays a vital role in the immune response by aiding in the recognition and binding of major histocompatibility complex (MHC) class I molecules. With a molecular weight of approximately 33 kDa, Recombinant Human CD8B, Sf9 serves as a co-receptor for the T-cell receptor, facilitating T-cell activation and cytotoxicity. This product is commonly used in research and biotechnology applications for its ability to modulate immune responses.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 85.0 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
17.8 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CD8B protein solution (0.5mg/ml) contains 10% glycerol & Phosphate Buffered Saline (pH 7.4).

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SPHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CD8B, Sf9

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