CD8B

Alternative Names: CD8 Antigen, Beta Polypeptide 1 (P37), CD8b Molecule, CD8b Antigen, T-Cell Surface Glycoprotein CD8 Beta Chain, CD8B1, LYT3, LY3, LEU2, P37, T Lymphocyte Surface Glycoprotein Beta Chain

CD8B is responsible for the production of CD8 beta chain variants, which are part of the CD8 antigen found on cytotoxic T lymphocytes. CD8 is a glycoprotein that supports effective cell-cell communication in the immune system. It is located on the surface of most cytotoxic T lymphocytes and works in conjunction with the T-cell receptor to recognize antigens displayed by antigen presenting cells. The co-receptor CD8 helps to identify these antigens by binding to class I MHC molecules. The co-receptor is made up of either a combination of one alpha and one beta chain or two alpha chains. Both the alpha and beta chains have significant similarity to immunoglobulin variable light chains.

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  • Sku: PSB-pro-1843-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human CD8B is a protein that plays a significant role in the immune system. Belonging to the CD8 family, it functions as a co-receptor for the T-cell receptor on cytotoxic T cells, aiding in the recognition of major histocompatibility complex class I molecules. With a weight of approximately 33 kDa, this protein is involved in the regulation of T cell activation and immune response. Its recombinant form is widely used in scientific research to study the intricate mechanisms of the immune system.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 80% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CD8B solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSLQQTPAY IKVQTNKMVM LSCEAKISLS NMRIYWLRQR QAPSSDSHHE FLALWDSAKG TIHGEEVEQE KIAVFRDASR FILNLTSVKP EDSGIYFCMI VGSPELTFGK GTQLSVVDFL PTTAQPTKKS TLKKRVCRLP RPETQKGPLC SP

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CD8B
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