CD3e

Alternative Names: T-cell surface antigen T3/Leu-4 epsilon chain, T-cell surface glycoprotein CD3 epsilon chain, CD3e, T3E, TCRE.

The CD3-epsilon polypeptide (CD3E) is part of the T-cell receptor-CD3 complex, together with CD3-gamma, -delta, -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers. This complex plays a crucial role in connecting antigen recognition with intracellular signal-transduction pathways. The epsilon, gamma, and delta polypeptide genes are located together on chromosome 11 and are involved in T-cell development. Defects in the CD3E gene lead to immunodeficiency, and in women, CD3E is associated with an increased risk of type I diabetes.

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  • Sku: PSB-pro-1317-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human CD3e is a protein that plays a critical role in the activation of T cells, a key component of the immune system. Belonging to the immunoglobulin superfamily, this protein is involved in the formation of the T cell receptor complex and subsequent signal transduction. With a molecular weight of approximately 20 kDa, Recombinant Human CD3e serves as an important target in various immunological research studies and therapeutic interventions. Its precise functioning and interaction with other molecules contribute to the understanding and advancement of immunological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
14.1 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CD3e solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.2M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSDGNEEMG GITQTPYKVS ISGTTVILTC PQYPGSEILW QHNDKNIGGD EDDKNIGSDE DHLSLKEFSE LEQSGYYVCY PRGSKPEDAN FYLYLRARVC ENCMEMD.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CD3e

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