CD320

Alternative Names: CD320 antigen isoform 1, CD320, 8D6, 8D6A, TCBLR, FDC-SM-8D6, FDC-signaling molecule 8D6

CD320 is a component of the low-density lipoprotein receptor family that includes 2 low-density lipoprotein receptor type A domains separated by a complement-like cysteine-rich region. CD320 is involved in cobalamin uptake and internalizes the complex via endocytosis. Furthermore, CD320 acts as a costimulator to enhance immune responses of B cells and follicular dendritic cells. Additionally, CD320 has been found to increase the proliferation of PC precursors generated by IL-10.

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  • Sku: PSB-pro-2428-2µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human CD320, also known as Cubilin, is a glycoprotein belonging to the family of low-density lipoprotein receptor-related proteins (LRPs). With a molecular weight of approximately 460 kDa, CD320 plays a significant role in the absorption of vitamin B12 and the reabsorption of various ligands in the renal proximal tubules. As a crucial component of the endocytic receptor complex, CD320 facilitates the internalization of ligands through clathrin-coated pits, contributing to the regulation of cellular homeostasis and nutrient uptake.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 90 % by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
47.4 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CD320 protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

LEAAASPLST PTSAQAAGPS SGSCPPTKFQ CRTSGLCVPL TWRCDRDLDC SDGSDEEECR IEPCTQKGQC PPPPGLPCPC TGVSDCSGGT DKKLRNCSRL ACLAGELRCT LSDDCIPLTW RCDGHPDCPD SSDELGCGTN EILPEGDATT MGPPVTLESV TSLRNATTMG PPVTLESVPS VGNATSSSAG DQSGSPTAYL EPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CD320

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