CD27

Alternative Names: CD27 Molecule, CD27 Antigen, CD27L Receptor, CD27, T-Cell Activation Antigen CD27, T Cell Activation Antigen S152, TNFRSF7, Tumor Necrosis Factor Receptor Superfamily Member 7, Tp55, T14

CD27 is a member of the TNF-receptor superfamily and plays a vital role in T cell immunity. Its binding to CD70 regulates B-cell activation and immunoglobulin synthesis. CD27 activates NF-kappaB and MAPK8/JNK signaling pathways through the interaction with adaptor proteins TRAF2 and TRAF5. Moreover, CD27-binding protein (SIVA) is thought to contribute to CD27-induced apoptosis.

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  • Sku: PSB-pro-1213-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human CD27 is a protein belonging to the tumor necrosis factor receptor superfamily. With a molecular weight of approximately 40 kDa, it plays a significant role in immune responses and T-cell activation. This protein is involved in the regulation of lymphocyte proliferation, differentiation, and survival. By binding to its ligand, CD70, CD27 initiates downstream signaling pathways that contribute to the activation and expansion of T-cells. Its precise functions make Recombinant Human CD27 a valuable target for research and potential therapeutic applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CD27 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMTPAPK SCPERHYWAQ GKLCCQMCEP GTFLVKDCDQ HRKAAQCDPC IPGVSFSPDH HTRPHCESCR HCNSGLLVRN CTITANAECA CRNGWQCRDK ECTECDPLPN PSLTARSSQA LSPHPQPTHL PYVSEMLEAR TAGHMQTLAD FRQLPARTLS THWPPQRSLC SSDFIR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CD27

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