CD247

Alternative Names: T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3 zeta chain, CD3-ZETA, CD3H, CD3Q, CD3Z, T3Z, TCRZ, CD247.

CD247, also known as T-cell surface glycoprotein CD3 zeta chain, belongs to the CD3Z/FCER1G family. It functions as the T-cell receptor zeta and forms the T-cell receptor-CD3 complex with T-cell receptor alpha/beta and gamma/delta heterodimers, as well as CD3-gamma, -delta, and -epsilon. CD247 plays a vital role in connecting antigen recognition to various intracellular signal-transduction pathways. Reduced CD247 expression leads to compromised immune response.

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  • Sku: PSB-pro-1335-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human CD247, also known as Cluster of Differentiation 247, is a protein belonging to the family of transmembrane signaling molecules. With a molecular weight of approximately 16 kDa, this protein plays a vital role in the activation of T cells and natural killer cells. It functions as a signaling subunit of the T-cell receptor complex, facilitating the transmission of intracellular signals upon antigen recognition. Recombinant Human CD247 is commonly used in research and biotechnology applications to investigate immune responses and develop therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 15.4 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CD247 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSRVKFSRS ADAPAYQQGQ NQLYNELNLG RREEYDVLDK RRGRDPEMGG KPQRRKNPQE GLYNELQKDK MAEAYSEIGM KGERRRGKGH DGLYQGLSTA TKDTYDALHM QALPPR.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CD247
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