CD1A

Alternative Names: CD1, CD1A, FCB6, HTA1, R4, T6, T-cell surface antigen T6/Leu-6, hTa1 thymocyte antigen.

CD1a is a transmembrane glycoprotein that resembles MHC proteins and combines with beta-2-microglobulin to form heterodimers. It plays a role in presenting lipid and glycolipid antigens to T cells, which can be of self or microbial origin. The human genome has a cluster of five CD1 family genes on chromosome 1. Each CD1 member is believed to have distinct cellular locations and specificities for different lipid ligands. This gene's protein is found on the plasma membrane and recycling vesicles of the early endocytic system. While various alternative spliced transcript variants exist, their biological significance remains undetermined.

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  • Sku: PSB-pro-2427-1µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human CD1A is a protein that belongs to the CD1 family, a group of transmembrane glycoproteins involved in antigen presentation. With a molecular weight of approximately 45 kDa, CD1A plays a crucial role in the immune response by presenting lipid antigens to T cells. This protein is expressed on the surface of antigen-presenting cells, such as dendritic cells and Langerhans cells, and is involved in the activation of T cells, thus contributing to the adaptive immune system. Understanding the function and structure of Recombinant Human CD1A is of great importance in immunological research and the development of therapeutic strategies.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Sf9 - Baculovirus cells
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
33.2 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CD1A protein solution (0.5mg/ml) containing Phosphate Buffered Saline (pH 7.4), and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ADPDGLKEPL SFHVTWIASF YNHSWKQNLV SGWLSDLQTH TWDSNSSTIV FLCPWSRGNF SNEEWKELET LFRIRTIRSF EGIRRYAHEL QFEYPFEIQV TGGCELHSGK VSGSFLQLAY QGSDFVSFQN NSWLPYPVAG NMAKHFCKVL NQNQHENDIT HNLLSDTCPR FILGLLDAGK AHLQRQVKPE AWLSHGPSPG PGHLQLVCHV SGFYPKPVWV MWMRGEQEQQ GTQRGDILPS ADGTWYLRAT LEVAAGEAAD LSCRVKHSSL EGQDIVLYWE HHSSVHHHHH H.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CD1A

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