CD14 HEK

Alternative Names: CD14, Monocyte differentiation antigen CD14, Myeloid cell-specific leucine-rich glycoprotein

CD14, also called lipopolysaccharide (LPS) receptor, is prominently expressed on monocytes and macrophages, and to a lesser extent on neutrophils. It is anchored to cells through glycosylphosphatidylinositol (GPI) linkage and acts as a high-affinity receptor for LPS-LBP complexes. Soluble CD14 can also bind to LPS and has both agonistic and antagonistic effects on cell activation, depending on its concentration. CD14 has been observed to bind apoptotic cells.

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  • Sku: PSB-pro-1642-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human CD14, HEK is a protein that belongs to the CD14 family, which is involved in the recognition and response to bacterial lipopolysaccharides (LPS). With a molecular weight of approximately X kDa, this protein plays a significant role in the innate immune system by facilitating the binding of LPS to Toll-like receptor 4 (TLR4) and subsequent activation of downstream signaling pathways. Its recombinant form, produced in Human Embryonic Kidney (HEK) cells, offers a valuable tool for studying immune responses and inflammatory processes in various research applications.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System HEK 293
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Monomer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation CD14 was lyophilized from a 0.2 µM filtered solution of 20mM PB and 150mM NaCl, PH 7.4.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

TTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACVDHHHHHH

Storage Instruction

Lyophilized CD14 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution CD14 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized CD14 in 1xPBS to a concentration no less than 100 µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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CD14 HEK

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