CBX5

Alternative Names: Heterochromatin protein 1 homolog alpha, Chromobox homolog 5 (HP1 alpha homolog, Drosophila), HP1Hs alpha, HP1 alpha homolog.

CBX5 is a member of the heterochromatin protein family and is mainly found in heterochromatin regions near centromeres. It plays a critical role in the formation of functional kinetochores by interacting with key kinetochore proteins. CBX5 has a pseudogene located on chromosome 3. Additionally, CBX5 proteins reassociate with chromatin after mitosis ends when Histone H3 becomes dephosphorylated.

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  • Sku: PSB-pro-1062-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Chromobox Homolog 5 (CBX5), belonging to the chromobox (CBX) family, is a protein encoded by the CBX5 gene. CBX5 is involved in various biological processes, including transcriptional regulation, chromatin remodeling, and DNA repair. With a molecular weight of approximately X kilodaltons (kDa), CBX5 plays a significant role in maintaining chromatin structure and gene expression patterns. Understanding the functions and mechanisms of CBX5 is crucial for unraveling its involvement in various cellular processes and its potential implications in disease development.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
24.8 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CBX5 solution (1mg/1ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 30% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMGKKTK RTADSSSSED EEEYVVEKVL DRRVVKGQVE YLLKWKGFSE EHNTWEPEKN LDCPELISEF MKKYKKMKEG ENNKPREKSE SNKRKSNFSN SADDIKSKKK REQSNDIARG FERGLEPEKI IGATDSCGDL MFLMKWKDTD EADLVLAKEA NVKCPQIVIA FYEERLTWHA YPEDAENKEK ETAKS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CBX5

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