CBX3

Alternative Names: Heterochromatin protein 1 homolog gamma, Chromobox homolog 3 (Drosophila HP1 gamma), HP1 gamma homolog, HP1Hs-gamma, Modifier 2 protein, HECH.

CBX3 participates in transcriptional silencing in heterochromatin-like complexes by binding to methylated histone H3 tails at 'Lys-9', leading to epigenetic repression. CBX3 also plays a role in the assembly of functional kinetochores by interacting with proteins from the MIS12 complex.

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  • Sku: PSB-pro-1057-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Chromobox Homolog 3 (CBX3), also known as HP1γ, is a protein belonging to the chromobox (CBX) family. CBX3 is involved in chromatin remodeling and plays a crucial role in gene expression regulation. With a molecular weight of approximately 20 kilodaltons, CBX3 is predominantly localized in the nucleus and forms heterochromatin, contributing to the maintenance of genome stability and integrity. It interacts with various proteins and serves as a key component in diverse cellular processes, including transcriptional repression and DNA repair.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
23.4 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CBX3 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 100mM Nacl, 1mM DTT and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMASNKT TLQKMGKKQN GKSKKVEEAE PEEFVVEKVL DRRVVNGKVE YFLKWKGFTD ADNTWEPEEN LDCPELIEAF LNSQKAGKEK DGTKRKSLSD SESDDSKSKK KRDAADKPRG FARGLDPERI IGATDSSGEL MFLMKWKDSD EADLVLAKEA NMKCPQIVIA FYEERLTWHS CPEDEAQ.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CBX3

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