CASQ2

Alternative Names: Calsequestrin cardiac muscle isoform, Calsequestrin-2, CASQ2, FLJ26321, FLJ93514, PDIB2.

CASQ2 is a calcium binding protein found in the sarcoplasmic reticulum of cardiac and slow skeletal muscle cells. It stores calcium for muscle function and releases it through a calcium release channel to activate muscle contraction. CASQ2 can bind 40 to 50 moles of calcium. However, mutations in CASQ2 can lead to stress-induced polymorphic ventricular tachycardia, commonly known as catecholaminergic polymorphic ventricular tachycardia 2, which is characterized by bidirectional ventricular tachycardia and can result in cardiac arrest.

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  • Sku: PSB-pro-799-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Calsequestrin is a protein that belongs to the calsequestrin family, which is involved in calcium storage and release within cells. With a molecular weight of approximately 53 kilodaltons, this protein plays a significant role in regulating calcium levels in the sarcoplasmic reticulum of muscle cells. By binding and releasing calcium ions, it aids in the proper functioning of muscle contraction and relaxation. Recombinant Human Calsequestrin is widely studied and utilized in scientific research to better understand calcium homeostasis and its implications in various physiological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CASQ2 solution contains 20mM Tris-HCl pH-8, 0.1M NaCl, 1mM DTT and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMEEG LNFPTYDGKD RVVSLSEKNF KQVLKKYDLL CLYYHEPVSS DKVTQKQFQL KEIVLELVAQ VLEHKAIGFV MVDAKKEAKL AKKLGFDEEG SLYILKGDRT IEFDGEFAAD VLVEFLLDLI EDPVEIISSK LEVQAFERIE DYIKLIGFFK SEDSEYYKAF EEAAEHFQPY IKFFATFDKG VAKKLSLKMN EVDFYEPFMD EPIAIPNKPY TEEELVEFVK EHQRPTLRRL RPEEMFETWE DDLNGIHIVA FAEKSDPDGY EFLEILKQVA RDNTDNPDLS ILWIDPDDFP LLVAYWEKTF KIDLFRPQIG VVNVTDADSV WMEIPDDDDL PTAEELEDWI EDVLSGKINT EDDDEDDDDD DNSDEEDNDD SDDDDDE.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CASQ2

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