CASP3

Alternative Names: Caspase 3 Apoptosis-Related Cysteine Peptidase, CPP32 Caspase 3 Apoptosis-Related Cysteine Protease, Cysteine Protease CPP32, Protein Yama, CASP-3, CPP-32, SCA-1, SREBP Cleavage Activity 1, EC 3.4.22.56, CPP32B, caspase-3, PARP Cleavage Protease, procaspase3, Apopain, EC 3.4.22, CASP3.

Caspase 3 (CASP3) is a member of the caspase family of cysteine-aspartic acid proteases, which are crucial for cell apoptosis. Inactive caspases are activated through proteolytic processing to form active enzymes. CASP3 cleaves and activates several other caspases, including those involved in Alzheimer's disease and huntingtin cleavage. CASP3 also plays a role in cell adhesion and activation of sterol regulatory element binding proteins (SREBPs) in neurons.

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  • Sku: PSB-enz-791-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Caspase 3 Apoptosis-Related Cysteine Peptidase is a member of the caspase family of cysteine proteases that play a key role in programmed cell death, or apoptosis. With a molecular weight of approximately 32 kDa, this enzyme is involved in the cleavage of various cellular proteins during apoptosis, ultimately leading to cell death. Recombinant Human Caspase 3 is commonly used in research studies to investigate the mechanisms of apoptosis and its implications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 80.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CASP3 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MSGVDDDMAC HKIPVEADFL YAYSTAPGYY SWRNSKDGSW FIQSLCAMLK QYADKLEFMH ILTRVNRKVA TEFESFSFDA TFHAKKQIPC IVSMLTKELY FYH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CASP3
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