CASP2

Alternative Names: Caspase-2, CASP-2, CASP2, Caspase 2 Apoptosis-Related Cysteine Peptidase, Caspase-2 subunit p18, Caspase-2 subunit p13, Caspase-2 subunit p12, Caspase 2 isoform 1, Protease ICH-1, ICH1, Neural precursor cell expressed developmentally down-regulated protein 2, NEDD-2, NEDD2, PPP1R57.

Caspase 2 (CASP2) is a cysteine protease involved in apoptosis activation. It plays a role in the cleavage of proteins necessary for cell survival in response to different apoptotic signals.

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  • Sku: PSB-enz-801-5µg
  • Vendor: ProSpec-Tany
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Title

Product Details

Product Description

Recombinant Human Caspase 2 Apoptosis-Related Cysteine Peptidase is a member of the caspase family of cysteine proteases, which play a key role in programmed cell death. With a molecular weight of approximately 48 kDa, this enzyme is involved in the initiation of apoptosis by cleaving specific substrates within the cell. Recombinant Human Caspase 2 Apoptosis-Related Cysteine Peptidase is a valuable tool for studying the mechanisms of apoptosis and its dysregulation in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 80.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
14.1 kDa
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation The CASP2 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MAGKEKLPKM RLPTRSDMIC GYACLKGTAA MRNTKRGSWY IEALAQVFSE RACDMHVADM LVKVNALIKD REGYAPGTEF HRCKEMSEYC STLCRHLYLF PGHPPT.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CASP2

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