CARD17

Alternative Names: CARD17, Caspase Recruitment Domain Family, Member 17, Caspase recruitment domain-containing protein 17, Caspase-1 inhibitor INCA, INCA, Inhibitory caspase recruitment domain protein.

CARD17 is a regulator that controls the activation of procaspase-1/CASP1, which is important for the maturation of pro-IL-1beta/IL1B and its release during inflammation. It prevents the release of IL1B in response to LPS in monocytes. However, unlike CASP1, it does not activate NF-kappa-B.

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  • Sku: PSB-pro-1688-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Caspase Recruitment Domain Family, Member 17 (CARD17) is a protein that belongs to the caspase recruitment domain (CARD) family. With a molecular weight of approximately X kDa, CARD17 plays a role in the regulation of immune and inflammatory responses. It acts as an adaptor protein, facilitating the recruitment and activation of caspases, which are crucial components of apoptotic pathways. Understanding the function and mechanisms of CARD17 can provide valuable insights into the intricate processes underlying immune system regulation and inflammation.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CARD17 solution (1mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 20% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSMADKVLK EKRKQFIRSV GEGTINGLLG ELLETRVLSQ EEIEIVKCEN ATVMDKARAL LDSVIRKGAP ACQICITYIC EEDSHLAGTL GLSAGPTSGN HLTTQDSQIV LPS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CARD17
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