CALM2

Alternative Names: Phosphorylase kinase delta, PHKD, PHKD2, Calmodulin-2, CAMII, CALM1 protein, CALM2.

Calmodulin-2 is an intracellular calcium sensor protein. It binds up to four Ca2+ ions, which causes a change in its shape and regulates various cellular functions, including activation or inhibition of enzymes, ion channels, and receptors. The P53 protein stimulates the expression of the CALM2 gene in 041 cells. CALM-2 plays a role in Ca(2+)-induced neuronal cell death and blocking calmodulin can help prevent brain injury after cerebral ischemia. Calmodulin-2 controls the activity of many enzymes and proteins through binding to Ca(2+). This includes various protein kinases and phosphatases that are stimulated by the calmodulin-Ca(2+) complex.

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  • Sku: PSB-pro-618-5µg
  • Vendor: ProSpec-Tany
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UniProt Listing
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Product Details

Product Description

Recombinant Human Calmodulin-2 is a protein that belongs to the calmodulin family, a group of calcium-binding proteins involved in regulating various cellular processes. With a molecular weight of approximately 16.7 kilodaltons, this protein plays a significant role in calcium signaling and acts as a crucial mediator of intracellular signaling pathways. Its binding to calcium ions enables the activation of numerous target proteins, thereby modulating their functions and impacting cellular activities. Recombinant Human Calmodulin-2 is widely studied in scientific research due to its pivotal involvement in diverse physiological and pathological processes.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CALM2 solution (1mg/ml) contains 20mM Tris-HCl, pH-7.5.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MADQLTEEQI AEFKEAFSLF DKDGDGTITT KELGTVMRSL GQNPTEAELQ DMINEVDADG NGTIDFPEFL TMMARKMKDT DSEEEIREAF RVFDKDGNGY ISAAELRHVM TNLGEKLTDE EVDEMIREAD IDGDGQVNYE EFVQMMTAK.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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CALM2
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