CALB1

Alternative Names: Calbindin 1 28kDa, Calbindin D28, CALB1, CAB27, CALB, calbindin, Vitamin D-dependent calcium-binding protein, avian-type

Calbindin 1 (CALB1) is a calcium binding protein that is part of the troponin C superfamily. It is involved in regulating calcium levels and associated signaling in neurons, as well as in embryological development. CALB1 also helps protect neurons from cell death and acts as a buffer for cytosolic calcium. Additionally, CALB1 has the ability to stimulate certain enzymes. Its function appears to be linked to the redox state of its five cysteine residues. CALB1 has four active calcium-binding domains and two modified domains that no longer bind calcium. It is expressed in neural tissues, including the brain where its synthesis is not influenced by vitamin-D-derived hormones. Abnormal regulation of CALB1 has been associated with epilepsy, amyotrophic lateral sclerosis, and Huntington's disease. In the brains of individuals with Huntington's disease, there is a reduction in calbindin levels in neurons.

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  • Sku: PSB-pro-721-10µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Calbindin-1 is a protein that belongs to the EF-hand calcium-binding protein family. With a weight of approximately 9.4 kDa, it plays a significant role in calcium homeostasis and signaling within cells. This protein is involved in various physiological processes, including neuronal development, synaptic plasticity, and muscle contraction. Recombinant Human Calbindin-1 is widely utilized in scientific research to investigate its functional properties and its potential implications in numerous pathological conditions.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The CALB1 protein solution contains 20mM Tris-HCl buffer (pH8.0), 1mM DTT, 10% glycerol and 2mM EDTA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MAESHLQSSL ITASQFFEIW LHFDADGSGY LEGKELQNLI QELQQARKKA GLELSPEMKT FVDQYGQRDD GKIGIVELAH VLPTEENFLL LFRCQQLKSC EEFMKTWRKY DTDHSGFIET EELKNFLKDL LEKANKTVDD TKLAEYTDLM LKLFDSNNDG KLELTEMARL LPVQENFLLK FQGIKMCGKE FNKAFELYDQ DGNGYIDENE LDALLKDLCE KNKQDLDINN ITTYKKNIMA LSDGGKLYRT DLALILCAGD N.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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CALB1
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