CADM1

Alternative Names: Not Available

Cell Adhesion Molecule 1, or CADM1, is a member of the nectin family that facilitates cell-cell adhesion. It does so both homophilically and heterophilically, in a Ca2+-independent manner. Moreover, CADM1 acts as a tumor suppressor in non-small-cell lung cancer (NSCLC) cells. It enhances the cytotoxicity of natural killer (NK) cells and promotes IFN-gamma secretion by CD8+ cells, when interacting with CRTAM in vitro. Additionally, in vivo, CADM1 aids in the rejection of tumors expressing CADM3 by NK cells.

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  • Sku: PSB-pro-2098-2µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Cell Adhesion Molecule 1 (RCAM-1) is a glycoprotein that plays a significant role in cell-cell adhesion and cellular signaling processes. Belonging to the immunoglobulin superfamily, RCAM-1 is involved in various physiological and pathological events, including immune responses, inflammation, and cancer progression. With a molecular weight of approximately X kDa, RCAM-1 is a crucial mediator in the regulation of cell adhesion and communication. Its significance lies in its ability to modulate cellular interactions and facilitate diverse biological processes, making it a promising target for therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 85.0% by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation CADM1 protein solution (0.25 mg/ml) containing Phosphate buffered saline (pH7.4), 10% glycerol and 1mM DTT.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSQNLFTKD VTVIEGEVAT ISCQVNKSDD SVIQLLNPNR QTIYFRDFRP LKDSRFQLLN FSSSELKVSL TNVSISDEGR YFCQLYTDPP QESYTTITVL VPPRNLMIDI QKDTAVEGEE IEVNCTAMAS KPATTIRWFK GNTELKGKSE VEEWSDMYTV TSQLMLKVHK EDDGVPVICQ VEHPAVTGNL QTQRYLEVQY KPQVHIQMTY PLQGLTREGD ALELTCEAIG KPQPVMVTWV RVDDEMPQHA VLSGPNLFIN NLNKTDNGTY RCEASNIVGK AHSDYMLYVY DPPTTIPPPT TTTTTTTTTT TTILTIITDS RAGEEGSIRA VDH.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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CADM1

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