C8G

Alternative Names: Complement component 8 gamma polypeptide, complement component C8 gamma chain, C8C, MGC142186.

C8, a part of the complement system, is made up of three polypeptides known as C8A, C8B, and C8G. This component participates in the creation of the Membrane Attack Complex (MAC). When patients lack C8, they become susceptible to bacterial infections. C8G, a secretion protein, belongs to the lipocalin family and calycin superfamily. It can bind retinol. C8G is produced in the liver, monocytes, and fibroblast and assists in the removal of pathogens in an infected individual.

  •
  • Sku: PSB-pro-947-5µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Complement Component 8, Gamma (C8γ) is a protein that belongs to the complement system, a crucial part of the immune response. It plays a vital role in the formation of the membrane attack complex, which aids in the destruction of foreign pathogens. C8γ has a molecular weight of approximately X kDa, making it a substantial component of the complement system. This recombinant protein holds significant potential for therapeutic applications in various immune-related disorders.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homotrimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The C8G solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 0.15M NaCl and 10% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MQKPQRPRRP ASPISTIQPK ANFDAQQFAG TWLLVAVGSA CRFLQEQGHR AEATTLHVAP QGTAMAVSTF RKLDGICWQV RQLYGDTGVL GRFLLQARGA RGAVHVVVAE TDYQSFAVLY LERAGQLSVK LYARSLPVSD SVLSGFEQRV QEAHLTEDQI FYFPKYGFCE AADQFHVLDE VRR

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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C8G
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