C5

Alternative Names: C5, C5D, C5a, C5a Anaphylatoxin, C5b, Complement Component 5, CPAMD4, Prepro-C5, ECLZB, C3 and PZP-Like Alpha-2-Macroglobulin Domain-Containing Protein 4, Anaphylatoxin C5a Analog.

Complement C5 is divided into two parts, C5a and C5b, and can be activated by any of the three pathways of complement activation. Each pathway generates enzyme complexes that bind to the target surface. These enzymes split a peptide bond in the larger alpha chain of C5, releasing the highly potent anaphylatoxin C5a and activating C5b. C5a is crucial in chemotaxis, while C5b is the first part of the complement membrane attack complex. Complement C5 is a crucial component involved in inflammation and cell killing.

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  • Sku: PSB-pro-2691-20µg
  • Vendor: ProSpec-Tany
$220.00 USD
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Title

Product Details

Product Description

Human Complement C5 is a glycoprotein that plays a significant role in the immune system's complement cascade. It belongs to the family of complement components, specifically the C5 component. With a molecular weight of approximately 190 kDa, it acts as a precursor to C5a and C5b fragments upon activation. C5 is involved in the opsonization of pathogens, recruitment of immune cells, and initiation of the membrane attack complex. Understanding the structure and function of Human Complement C5 is crucial for unraveling the intricacies of the immune response and developing therapeutic interventions.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation C5 protein solution contains 10mM sodium phosphate, 145mM NaCl, pH 7.2.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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C5

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