C4a

Alternative Names: Acidic complement C4, Complement C4-A, C4A, CO4, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 2, CPAMD2.

Natural human C4a is formed through the cleavage of human C4 by human C1s. It is produced in both the lectin and classical pathways of complement activation. C4a is a non-glycosylated polypeptide consisting of 77 amino acids. It belongs to the anaphylatoxin family, which includes three proteins (C3a, C4a, and C5a) generated during complement activation.

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  • Sku: PSB-pro-2689-10µg
  • Vendor: ProSpec-Tany
$385.00 USD
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Title

Product Details

Product Description

Human Complement C4a is a protein fragment that plays a significant role in the immune system as part of the complement system. Belonging to the family of complement components, C4a is involved in the activation of the immune response against foreign pathogens. With a molecular weight of approximately 190 kDa, this protein fragment acts as an opsonin, facilitating the recognition and elimination of pathogens by immune cells. Its precise role in immune regulation and defense mechanisms makes Human Complement C4a a subject of interest in various research fields, including immunology and infectious diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation C4a protein solution contains HEPES buffered saline, pH 7.2.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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C4a

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