C3c

Alternative Names: Complement C3c, C3c, Complement Component C3c.

The C3c component is important in both complement activation pathways. It is cleaved by specific proteolytic systems to form C3 convertase, which releases C3a and the C3b fragment. C3 levels can be low due to decreased synthesis or consumption, while high levels are associated with acute or chronic inflammation, hepatic cholestasis, and late-stage pregnancy. Unwanted complement activation causes tissue damage in various pathological conditions and immune complex diseases. Compstatin is an effective inhibitor of C3 activation, blocking a crucial step in the complement cascade. The specific binding site and mode of action of compstatin on C3 are unknown. The crystal structure of compstatin in complex with C3c shows that it binds to the 4th and 5th domains of the macroglobulin (MG) region. This binding site is part of the structurally stable MG-ring formed by domains MG1-6 and is not near any other known C3 binding site. Compstatin does not affect the conformation of C3c, but it undergoes a significant conformational change upon binding.

  •
  • Sku: PSB-pro-555-200µg
  • Vendor: ProSpec-Tany
$90.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Complement Component C3c is a vital protein fragment involved in the complement system, a crucial part of the immune response. Belonging to the family of complement components, C3c plays a pivotal role in the opsonization process and immune complex clearance. With a molecular weight of approximately 185 kDa, C3c acts as an intermediary in the complement cascade, facilitating the recognition and elimination of foreign pathogens. Its significance lies in its ability to promote inflammation, phagocytosis, and immune cell activation, making it an integral component in the defense against infections and maintaining immune homeostasis.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 96.0% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Contact for Details
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The Human Complement C3c was lyophilizedin a sodium phosphate buffer, pH 7.2, containing 0.15M NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

C3c Beta chain (23-667)

Storage Instruction

Human C3c although stable at room temperature for 3 weeks, should be stored between 2-8°C. Human C3c although stable at room temperature for 3 weeks, should be stored between 2-8°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized C3c in de-ionized water.

References

Not Available
View full details

C3c
SUBHEADING

Recently viewed products