C3a

Alternative Names: Complement C3, C3, CPAMD1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1.

Native human C3a is produced through the cleavage of human C3 protein by a human C3 convertase. C3a belongs to the anaphylatoxin family comprising C3a, C4a, and C5a, which are formed upon complement activation. C3a is responsible for various inflammatory responses such as smooth muscle contraction, increased vascular permeability, vasodilation, and the release of histamine from mast cells and basophils. Unlike C5a, C3a does not have significant neutrophil stimulating effects and does not induce chemotaxis, granule release, or superoxide production. C3a exerts its effects by binding to the C3a Receptor, a G-protein coupled receptor found primarily in peripheral tissues, lymphoid cells, and in the central nervous system. The activities of C3a can be deactivated by the removal of the C-terminal arginine residue, which occurs rapidly in plasma through the action of carboxypeptidase N.

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  • Sku: PSB-pro-2685-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Complement C3a is a small peptide that plays a significant role in the immune response. Belonging to the family of anaphylatoxins, it is a crucial component of the complement system, a cascade of proteins that aids in the body's defense against pathogens. With a molecular weight of approximately 9 kDa, Human Complement C3a is involved in various immune processes, including inflammation and chemotaxis. Understanding the functions and characteristics of this peptide is essential for comprehending the intricate workings of the immune system.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 98.0 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation C3a solution contains Phosphate buffered saline, pH 7.2.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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C3a
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