C2

Alternative Names: Complement C2, C2, C3/C5 convertase.

C2 is an important component of the proteolytic subunit in the C3 and C5 convertase of both pathways. The initiation of each pathway leads to the formation of enzyme complexes that bind to the surface they target. These complexes, containing C1s and MASP, activate both C4 and C2 molecules. They break a peptide bond in C4, resulting in C4b being deposited on the surface, and also cleave C2 into two fragments.

  •
  • Sku: PSB-pro-2683-10µg
  • Vendor: ProSpec-Tany
$385.00 USD
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Human Complement C2 is a glycoprotein that plays a significant role in the innate immune response as part of the complement system. Belonging to the family of serine proteases, this protein is involved in the activation of the complement cascade, which aids in the elimination of pathogens and immune complex clearance. With a molecular weight of approximately 110 kDa, Human Complement C2 is synthesized in the liver and circulates in the blood, contributing to the opsonization and lysis of foreign invaders. Understanding the functional properties and regulatory mechanisms of Human Complement C2 is crucial for comprehending the innate immune response and its implications in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System Human Plasma
Purity 95.0 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation 25mM sodium phosphate and 100mM NaCl, pH 6.0.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

Check Uniprot Link

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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C2
SUBHEADING

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