bPF4

Alternative Names: CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298

Platelet factor-4 (PF4) is a 70-amino acid protein released from activated platelets. PF4 neutralizes molecules on endothelial blood vessel surfaces, inhibiting antithrombin III activity and promoting coagulation. It also acts as a chemoattractant for neutrophils and fibroblasts, playing a role in inflammation and wound repair. Oncostatin-A, a member of the CXC chemokine family, is used as an inhibitor in tumor therapy to interfere with angiogenesis.

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  • Sku: PSB-chm-039-50µg
  • Vendor: ProSpec-Tany
$600.00 USD
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Title

Product Details

Product Description

Recombinant Bovine Platelet Factor-4 (CXCL4) is a chemokine belonging to the CXC subfamily. With a molecular weight of approximately 7.8 kDa, CXCL4 plays a role in inflammation and immune response regulation. As a member of the chemokine family, CXCL4 is involved in the recruitment and activation of leukocytes at sites of injury or infection. Its ability to modulate immune cell function makes CXCL4 a valuable tool in research and therapeutic applications related to inflammatory diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
Bovine
Expression System E. coli
Purity 95.0 % by SDS-PAGE
Activity
The biological activity determined by a chemotaxis bioassay using human neutrophils is 10-100ng/ml.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Dimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Lyophilized
Formulation Lyophilized from a 0.2μm filtered concentrated solution in 20 mM PB and 500mM NaCl, pH 7.0.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ESSFPATFVP LPADSEGGED EDLQCVCLKT TSGINPRHIS SLEVIGAGTH CPSPQLLATK KTGRKICLDQ QRPLYKKILK KLLDGDES.

Storage Instruction

Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C. Store lyophilized protein at -20°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4°C for a limited period of time; it does not show any change after two weeks at 4°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Platelet Factor-4 in sterile 18MΩ-cm H₂O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available

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bPF4

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