BIRC7 (1-280)

Alternative Names: Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Melanoma inhibitor of apoptosis protein, RING finger protein 50, KIAP, MLIAP, ML-IAP, LIVIN, BIRC7.

BIRC7 is a member of the inhibitor of apoptosis protein (IAP) family, characterized by having a BIR repeat and a RING finger domain. The BIR domain is crucial for inhibitory activity and works alongside caspases. The RING finger domain can enhance anti-apoptotic activity, but does not inhibit apoptosis on its own. This gene has two transcript variants that produce different isoforms. These isoforms have different abilities to protect cells from apoptosis induced by staurosporine and etoposide. BIRC7 directly interacts with several caspases, including caspase-3, caspase-7, and caspase-9. BIRC7 prevents the activation of caspase-9 caused by Apaf-1, cytochrome c, and dATP.

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  • Sku: PSB-pro-1042-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human Baculoviral IAP Repeat-Containing 7 (1-280 a.a.) is a protein fragment derived from the human BIRC7 gene. Belonging to the inhibitor of apoptosis (IAP) protein family, it plays a regulatory role in the apoptotic pathway. With a molecular weight of approximately 31.3 kDa, this recombinant protein is commonly utilized in scientific research to investigate cellular mechanisms and signaling pathways associated with cell death and survival. Its precise and controlled expression allows for detailed analysis, making it a valuable tool in the field of molecular biology.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 90% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 33.4 kDa
Structure Monomer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation BIRC7 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 2mM DTT, 40% glycerol, 300mM NaCl and 1mM EDTA.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGSHMGPKDS AKCLHRGPQP SHWAAGDGPT QERCGPRSLG SPVLGLDTCR AWDHVDGQIL GQLRPLTEEE EEEGAGATLS RGPAFPGMGS EELRLASFYD WPLTAEVPPE LLAAAGFFHT GHQDKVRCFF CYGGLQSWKR GDDPWTEHAK WFPSCQFLLR SKGRDFVHSV QETHSQLLGS WDPWEEPEDA APVAPSVPAS GYPELPTPRR EVQSESAQEP GARDVEAQLR RLQEERTCKV CLDRAVSIVF VPCGHLVCAE CAPGLQLCPI CRAPVRSRVR TFLS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
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References

Not Available
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BIRC7 (1-280)
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