BIRC7

Alternative Names: Baculoviral IAP repeat-containing protein 7, Kidney inhibitor of apoptosis protein, Melanoma inhibitor of apoptosis protein, RING finger protein 50, KIAP, MLIAP, ML-IAP, LIVIN, BIRC7.

BIRC7 is a member of the inhibitor of apoptosis protein (IAP) family, containing a single baculovirus IAP repeat (BIR) and a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and works together with caspases. The RING finger domain, on the other hand, can enhance anti-apoptotic activity but does not inhibit apoptosis alone. Two different transcript variants have been identified for this gene, encoding diverse isoforms. These isoforms, designated as a and b, have distinct antiapoptotic characteristics. Isoform a protects cells from apoptosis induced by staurosporine, while isoform b defends cells from apoptosis in general. BIRC7 interacts directly with multiple caspases, including caspase-3, caspase-7, and caspase-9. It inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.

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  • Sku: PSB-pro-612-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Title

Product Details

Product Description

Recombinant Human Baculoviral IAP Repeat-Containing 7, also known as BIRC7, is a protein belonging to the inhibitor of apoptosis (IAP) family. This protein plays a crucial role in regulating programmed cell death, or apoptosis, by inhibiting caspases, the key enzymes responsible for initiating apoptosis. With a molecular weight of approximately X kilodaltons, BIRC7 functions as a potent anti-apoptotic protein, promoting cell survival and proliferation. Its significance lies in its ability to modulate apoptotic pathways, making it an intriguing target for therapeutic interventions aimed at controlling cell death.

Current Lead Time

7-14 Days

Product Specifications

Species
Human
Expression System E. coli
Purity 90.0 by SDS-PAGE
Activity
Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
N/A
Structure Homodimer
Endotoxin Concentration
Not Available
Purification Method Not Available
Form
Frozen
Formulation BIRC7 protein solution (1mg/ml) containing 20mM Tris pH-8, 1mM DTT, 0.1M NaCl, 2mM EDTA and 20% glycerol.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MGSSHHHHHH SSGLVPRGSH MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELRLASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution

References

Not Available

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BIRC7

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