bIGF1

Alternative Names: IGF-I, IGF1, IGF-IA, IGFI, Somatomedin C, Mechano growth factor, MGF

The IGFs are a group of peptides that are crucial for mammalian growth and development. IGF1 is responsible for many of the growth-promoting effects of growth hormone. Early research found that growth hormone does not directly impact the incorporation of sulfate into cartilage, but instead acts through a serum factor known as 'sulfation factor', which later became 'somatomedin'. Three main somatomedins have been identified: IGF1, somatomedin A, and somatomedin B. IGF-1, mainly produced by the liver, circulates in the blood bound to IGF binding proteins. It plays a role in regulating growth, acts similarly to insulin, stimulates cell division, and is released in response to growth hormone stimulation.

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  • Sku: PSB-cyt-427-10µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Rabbit Insulin Like Growth Factor-1 (rRIGF-1) is a protein belonging to the insulin-like growth factor family. With a molecular weight of approximately 7.5 kDa, rRIGF-1 plays a key role in cell growth, proliferation, and differentiation. This recombinant protein is commonly used in research studies to investigate the mechanisms underlying cellular growth and development. Its high purity and bioactivity make rRIGF-1 a valuable tool for studying various physiological processes in vitro.

Current Lead Time

7-14 Days

Product Specifications

Species
 Rabbit
Expression System E. coli
Purity 98.0 by SDS-PAGE
Activity
 IGF-I is biologically active when compared to human IGF-1. The ED50, calculated by the dose -dependent proliferation of human MCF/7 cells is 5 to 25ng/ml in the cell culture mixture dependent on culture conditions. Its activity consists of 30-40 % compared to human IGF-1. IGF-I is biologically active when compared to human IGF-1. The ED50, calculated by the dose -dependent proliferation of human MCF/7 cells is 5 to 25ng/ml in the cell culture mixture dependent on culture conditions. Its activity consists of 30-40 % compared to human IGF-1.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The protein was lyophilized from a concentrated (0.5mg/ml) solution with 0.02% NaHCO3.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MTAGPETLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKP

Storage Instruction

Lyophilized Insulin-Like Growth Factor-1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF1 should be stored at 4°C between 2-7 days and for future use below -18°C.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized rbIGF-I in sterile 0.4% NaHCO3 adjusted to ph 8-9, not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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bIGF1
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