BID

Alternative Names: BID, BH3-interacting domain death agonist, p22 BID, FP497, MGC15319, MGC42355.

BID, an apoptotic protein, interacts with Bax to form a heterodimer that inserts Bax into the mitochondrial membrane. This leads to the opening of the mitochondrial voltage-dependent anion channel, resulting in the release of cytochrome c and other pro-apoptotic factors. BID is also involved in mitochondrial damage induced by CASP8. CASP8 cleaves BID, causing the translocation of the COOH-terminal part to mitochondria and triggering cytochrome c release. The major proteolytic product, p15 BID, releases cytochrome c. While Isoform 1, Isoform 2, and Isoform 4 induce apoptosis and activate ice-like proteases, Isoform 3 does not induce apoptosis.

  •
  • Sku: PSB-pro-627-2µg
  • Vendor: ProSpec-Tany
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Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human BH3 Interacting Domain Death Agonist (RHBD-DA) is a protein belonging to the BH3-only family, which plays a critical role in regulating programmed cell death or apoptosis. With a molecular weight of approximately X kDa, RHBD-DA functions by binding to anti-apoptotic proteins, thereby neutralizing their inhibitory effect on apoptosis. This interaction promotes the release of pro-apoptotic factors, ultimately leading to cell death. RHBD-DA's significance lies in its ability to modulate apoptosis, making it a promising target for therapeutic interventions in various diseases.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Heterodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation The protein solution contains 20mM Tris-HCl pH-8 & 20% NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD.

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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BID
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