BD4

Alternative Names: HBD-4, HBD4, DEFB-4, DEFB104B, Beta-defensin 4, BD-4

Defensins are cationic peptides with broad antimicrobial activity, playing a key role in the innate immune system. Beta-defensins, distinct from Alpha defensins due to their 3 disulfide bonds, include human BD-1, BD-2, BD-3, and BD-4. These peptides are found on leukocytes and epithelial surfaces, attracting dendritic cells and memory T cells in addition to their direct antimicrobial effects. Beta-defensins are released as cleaved fragments from precursors, containing a six-cysteine motif forming three disulfide bonds. Ranging from 3-5 kDa and 33-47 amino acids in size, beta-defensins are a vital component of the immune response.

  •
  • Sku: PSB-cyt-599-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
Shipping calculated at checkout.

Contact us directly for international purchases.

Title
Report Product Listing Issue (e.g. Missing Data, or Questions)
Safety Data Sheet
UniProt Listing
NCBI Link

Product Details

Product Description

Recombinant Human Beta Defensin-4 is a protein belonging to the defensin family, known for its antimicrobial properties. With a molecular weight of approximately 4 kDa, this peptide plays a role in the innate immune response by targeting and neutralizing pathogens. Recombinant Human Beta Defensin-4 is commonly used in research settings to study host defense mechanisms and potential therapeutic applications in combating infections.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 98% by SDS-PAGE
Activity
 Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-50 ng/ml, corresponding to a specific activity of 20,000-10,000,000 units/mg. Determined by its ability to chemoattract human monocytes using a concentration range of 0.1-50 ng/ml, corresponding to a specific activity of 20,000-10,000,000 units/mg.
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation The DEFB4 (1mg/ml) was lyophilized with 20mM sodium Phosphate buffer pH-7.4 and 130mM NaCl.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

EFELDRICGY GTARCRKKCR SQEYRIGRCP NTYACCLRKW DESLLNRTKP.

Storage Instruction

Lyophilized Beta Defensin-4 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution BD-3 should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Beta Defensin-4 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
View full details

BD4
SUBHEADING

Recently viewed products