bCollagen-IV

Alternative Names: Not Available

Collagen, an important component of the extracellular matrix, is a fibrous protein that provides structural integrity and strength to tissues. It has been widely used in various fields for over a century due to its abundance and low cost. However, most collagen formulations are not highly purified and can cause inflammation in some users. There are also concerns about contamination with agents that cause diseases like mad cow disease. Animal collagens undergo extensive modifications throughout their lifespan, leading to variability between different batches. This makes them difficult to analyze. Furthermore, products containing animal collagen can trigger harmful immune reactions in humans and carry a risk of virus or prion contamination. Recombinant collagens, on the other hand, are virtually identical to natural collagen, resulting in reduced risk of inflammation, immune response, and disease compared to collagen derived from animals.

  •
  • Sku: PSB-pro-2678-250µg
  • Vendor: ProSpec-Tany
$275.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Bovine Collagen-IV is a structural protein that plays a vital role in maintaining the integrity and stability of various tissues in mammals, including humans. Belonging to the collagen family, it is a fibrous protein consisting of three polypeptide chains tightly intertwined to form a triple helix structure. With a molecular weight of approximately 400 kDa, Bovine Collagen-IV provides structural support to basement membranes, contributing to the maintenance of tissue architecture and cellular functions. Its significance lies in its ability to regulate cell adhesion, migration, and differentiation processes, making it a crucial component in various biological and biomedical applications.

Current Lead Time

7-14 Days

Product Specifications

Species
 Bovine
Expression System Bovine placenta
Purity 90 by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) No
Molecular Weight
 N/A
Structure Dimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Lyophilized
Formulation Collagen-IV was lyophilized without additives.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Storage Instruction

Lyophilized Collagen-IV although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Collagen-IV should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Sample Prep Instruction

It is recommended to reconstitute the lyophilized Collagen-IV in 20 mM acetic acid not less than 1mg/ml, which can then be further diluted to other aqueous solutions.

References

Not Available
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bCollagen-IV
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