BCL2L2

Alternative Names: B-Cell Lymphoma Protein 2, BCL2L2, BCL2 Like 2, BCL2 Like protein 2, BCL-W, Bcl2-L-2, Apoptosis regulator Bcl-W, KIAA0271.

BCL2L2 is a protein that promotes cell survival by inhibiting cell death. It specifically acts on postmitotic Sertoli cells by suppressing the activity of BAX, a protein that promotes cell death. BCL2L2 is a member of the BCL-2 protein family, which has both anti and proapoptotic properties and form dimers. BCL2L2 helps reduce cell apoptosis in conditions where cytotoxicity is present. Additionally, it is involved in the survival of neurons that depend on NGF and BDNF. BCL2L2 also plays a crucial role in adult spermatogenesis.

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  • Sku: PSB-pro-1577-5µg
  • Vendor: ProSpec-Tany
$60.00 USD
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Safety Data Sheet
UniProt Listing
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Product Details

Product Description

Recombinant Human BCL2 Like 2, also known as BCL2L2, is a protein that belongs to the BCL2 family. This family of proteins plays a critical role in regulating cell survival and apoptosis. BCL2L2 has a molecular weight of approximately X kDa. It functions by inhibiting cell death, thereby promoting cell survival. This recombinant protein is widely used in scientific research to investigate the molecular mechanisms underlying cell survival and apoptosis.

Current Lead Time

7-14 Days

Product Specifications

Species
 Human
Expression System E. coli
Purity 95% by SDS-PAGE
Activity
 Not Available
Activity Assay
Animal Component Free (ACF) Yes
Molecular Weight
 18.6 kDa
Structure Homodimer
Endotoxin Concentration
 Not Available
Purification Method Not Available
Form
 Frozen
Formulation BCL2L2 is a 0.2µm filtered concentrated solution which contains 25 mM Hepes, pH 7.4, 100 mM KCl, 10 % Glycerol, 5 % Trehalose, and 0.02 % Tween-80.

*For Research Use Only

Product Guarantee

If your product is within its expiration period, and has not performed according to expectations, fill out the sample return form. Return the unused sample frozen, with the auto generated packing slip to the address on the instructions. You will receive a full refund along with a replacement of the unused portion (inclusive of the failed test). Damages do not cover any additional costs incurred for failed experimentation. 

Amino Acid Sequence

ATPASAPDTR ALVADFVGYK LRQKGYVCGA GPGEGPAADP LHQAMRAAGD EFETRFRRTF SDLAAQLHVT PGSAQQRFTQ VSDELFQGGP NWGRLVAFFV FGAALCAESV NKEMEPLVGQ VQEWMVAYLE TQLADWIHSS GGWAEFTALY GDGALEEARR LREGNWASVR T

Storage Instruction

Reconstituted store at -20°C or -80°C.We recommend that single use aliquots are prepared to avoid freeze-thaw cycles.

Sample Prep Instruction

1. Thaw the vial on ice, spin briefly
2. Prepare single-use or stock aliquots. This stage will depend on your final application so please adapt as appropriate. All our proteins are supplied carrier protein-free. If compatible with your work and you are storing at lower concentrations (<50 ug/ml) adding carrier protein is highly advised (usually 1% w/v high purity BSA or equivalent – ensure all buffers are sterile-filtered).
3. Prepare single-use aliquots whenever possible to avoid freeze-thaw cycles which can damage the proteins and reduce bioactivity. Store aliquots at -70 °C (or -20 °C)
4. We recommend sterile filtering after dilution in media or the final working solution
​

References

Not Available
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BCL2L2
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